The handle on the top of the unit should be up. If it is down, pull it up. It is important to note that the writing on the front of the AnySharp should be facing away from you when using it. Place on the surface, and move the handle down. The suction PowerGrip will hold the AnySharp firmly in place. Just put your knife into the sharpening jaw, apply a light pressure, and pull the knife slowly towards you.
Be sure to apply only light pressure and gentle strokes as you draw your knife through your AnySharp. You are using the correct pressure if the action is smooth, and you get tiny metal filings coming off the knife. If you get no filings at all, or the motion is jerky or sticky, adjust the pressure to suit. The knife edge always faces away from you, and your hands are never near the cutting edge at any time.